N-(2-Chloropyrimidin-4-yl)-2-methyl-2H-indazol-6-amine methanol monosolvate
نویسندگان
چکیده
In the title compound, C(12)H(10)ClN(5)·CH(3)OH, the indazole ring system and the pyrimidine ring make a dihedral angle of 23.86 (4)°. In the crystal, the components are linked by N-H⋯O and O-H⋯N hydrogen bonds into chains propagated in [010]. Inter-molecular π-π inter-actions [centroid-centroid distances = 3.6404 (9), 3.6725 (9) and 3.4566 (9) Å] between the rings of neighbouring chains also stabilize the crystal packing.
منابع مشابه
N-(2-Chloropyrimidin-4-yl)-N,2-dimethyl-2H-indazol-6-amine
In the title compound, C(13)H(12)ClN(5), which is a derivative of the anti-tumor agent pazopanib {systematic name: 5-[[4-[(2,3-di-methyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrim-idine fragments form a dihedral angle of 62.63 (5)°. In the crystal, pairs of mol-ecules related by twofold rotational symmetry are linked into dimers through ...
متن کاملAqua[1-(1,10-phenanthrolin-2-yl-κ2 N,N′)-1H-pyrazol-3-amine-κN 2](sulfato-κO)copper(II) methanol monosolvate dihydrate
In the title compound, [Cu(SO(4))(C(15)H(11)N(5))(H(2)O)]·CH(3)OH·2H(2)O, the Cu(II) ion is in a distorted square-pyramidal geometry, in which three N atoms from the chelating 1-(1,10-phenanthrolin-2-yl)-1H-pyrazol-3-amine ligand and one O atom from a sulfate anion define the basal plane and the O atom from the coordinating water mol-ecule is located at the apex. In the crystal, hydrogen-bondin...
متن کاملNitrofurantoin methanol monosolvate
The anti-biotic nitro-furan-toin {systematic name: (E)-1-[(5-nitro-2-fur-yl)methyl-idene-amino]-imidazolidine-2,4-dione} crys-tallizes as a methanol monosolvate, C(8)H(6)N(4)O(5)·CH(4)O. The nitro-furan-toin mol-ecule adopts a nearly planar conformation (r.m.s. deviation = 0.0344 Å). Hydrogen bonds involve the co-operative N-H⋯O-H⋯O heterosynthons between the cyclic imide of nitro-furan-toin an...
متن کامل4-(3-Phenyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)benzenesulfonamide ethanol monosolvate
In the title compound ethanol monosolvate, C(23)H(21)N(3)O(2)S·C(2)H(5)OH, the dihydro-pyrazole ring is twisted about the Csp(3)-Csp(3) bond. Nevertheless, the ring approximates a plane (r.m.s. deviation for the fitted atoms = 0.132 Å) and forms dihedral angles of 5.80 (13) and 12.29 (12)°, respectively, with the fused- and sulfonamide-benzene rings. As the dihydro-pyrazole C-bound phenyl group...
متن کاملProapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) leads to rapid cell death of T-ALL lines and patient samples. Treatment of CEM, Jurkat, and MOLT-4 cells with nanomolar doses of the inhibitor led to AKT ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 67 شماره
صفحات -
تاریخ انتشار 2011